Recently, as invited by Chemical Reviews, the research group of Prof. Yiping Cui and Prof. Zhuyuan Wang published a review article entitled “SERS-Activated Platforms for Immunoassay: Probes Encoding Methods, and Applications” (Chemical Reviews, 2017, 117, 7910–7963, IF: 47.928). The review article can provide important theoretical and technical supports for researchers working on SERS based immunoassays.
On microfluidics, the research group developed a high-throughput microfluidic chip for screening immunotherapeutic drugs of cancerous diseases. The microfluidic chip can evaluate the pharmaceutical effects of the drugs as well as monitor the intercellular communications (Nano Research, 2017, 10, 584-594). They also proposed a microfluidic chip for the“on-line” detection of intracellular pharmacokinetics, which utilized SERS spectra to analyze the metabolism dynamics of drugs.In addition, they designed a microfluidic chip for the detection of microRNAs, which combined SERS and fluorescence spectroscopic techniques to achieve a better detection performance (Nanotechnology, 2017, 28, 105501).
On optical super-resolution imaging, the research group constructed a yolk-shell type “blinking” fluorescent nanoparticle, which can be used for super-resolution imaging of living cells (Nanotechnology, 28, 265701). They also proposed a novel immunofluorescent labeling strategy for super-resolution imaging of microtubules, which can achieve an extraordinary specificity and labeling density (RSC Advances, 2017, 7, 39977-39988).
Schematic illustration of SERS platforms for immunoassays
